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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Matairesinol, Fluorouracil
Phytochemical Name Matairesinol (PubChem CID: 119205 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 347
Ref_1
Pair Name Matairesinol, Fluorouracil
Disease Info [ICD-11: 2C10] Pancreatic cancer Investigative
Biological Phenomena Induction-->Mitochondrial dysfunction
Gene Regulation Up-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BAX hsa581
Down-regulation Expression FOXM1 hsa2305
Up-regulation Phosphorylation MAPK14 hsa1432
Down-regulation Expression PCNA hsa5111
Down-regulation Expression PLAU hsa5328
Down-regulation Expression VEGFA hsa7422
In Vitro Model MIA PaCa-2 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0428
PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0480
Result Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells
03. Reference
No. Title Href
1 Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells. Mar Drugs. 2022 Jul 25;20(8):473. doi: 10.3390/md20080473. Click
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